![](/CAS/GIF/40134-18-7.gif)
METHYL 2-CHLORONICOTINATE synthesis
- Product Name:METHYL 2-CHLORONICOTINATE
- CAS Number:40134-18-7
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-Chloronicotinic acid](/CAS/GIF/2942-59-8.gif)
2942-59-8
782 suppliers
$5.00/25g
![METHYL 2-CHLORONICOTINATE](/CAS/GIF/40134-18-7.gif)
40134-18-7
225 suppliers
$6.00/5g
Yield:40134-18-7 93%
Reaction Conditions:
with thionyl chloride for 8 h;Reflux;
Steps:
1.1 preparation of compound II
To the 250 ml flask is added in three 15.76g (0.1 µM) 2 - chloro -3 - picolinic acid, 100 ml methanol, under the ice-bath adds by drops 17.85g (0.15 µM) thionyl chloride, stirring and heating to reflux, the stirring reaction 8h. Thin layer chromatography tracking response, the raw materials point disappears, stopping the reaction. Reduced pressure distillation to remove the solvent to obtain light yellow 15.95g, yield 93%
References:
Qingdao University of Science and Technology;Wang Minghui;Yuan Jianpo;Huang Xuesong;Xu Liangzhong CN105061399, 2017, B Location in patent:Paragraph 0010; 0029; 0030
![2-Chloronicotinic acid](/CAS/GIF/2942-59-8.gif)
2942-59-8
782 suppliers
$5.00/25g
![METHYL 2-CHLORONICOTINATE](/CAS/GIF/40134-18-7.gif)
40134-18-7
225 suppliers
$6.00/5g
![2-Chloronicotinic acid](/CAS/GIF/2942-59-8.gif)
2942-59-8
782 suppliers
$5.00/25g
![Dimethyl sulfate](/CAS/GIF/77-78-1.gif)
77-78-1
289 suppliers
$19.69/1ml
![METHYL 2-CHLORONICOTINATE](/CAS/GIF/40134-18-7.gif)
40134-18-7
225 suppliers
$6.00/5g
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
739 suppliers
$7.29/5ml-f
![2-Chloronicotinyl chloride](/CAS/GIF/49609-84-9.gif)
49609-84-9
230 suppliers
$20.00/5g
![METHYL 2-CHLORONICOTINATE](/CAS/GIF/40134-18-7.gif)
40134-18-7
225 suppliers
$6.00/5g
![2-Chloronicotinic acid](/CAS/GIF/2942-59-8.gif)
2942-59-8
782 suppliers
$5.00/25g
![METHYL 2-CHLORONICOTINATE](/CAS/GIF/40134-18-7.gif)
40134-18-7
225 suppliers
$6.00/5g