methyl 2-cycloheptylacetate synthesis
- Product Name:methyl 2-cycloheptylacetate
- CAS Number:14224-70-5
- Molecular formula:C10H18O2
- Molecular Weight:170.25
Yield:14224-70-5 92.9%
Reaction Conditions:
with sulfuric acid at 70; for 16 h;
Steps:
Methyl 2-cycloheptylacetate
Methyl 2-cycloheptylacetate To a solution of 2-cycloheptylacetic acid (4.76g, 30.5 mmol) in methanol (50mL) was added sulfuric acid (2.99 g, 30.5 mmol) slowly. Then it was stirred at 70°C for 16 h. After it was cooled to ambient temperature, the reaction mixture was added to 50 mL of water and extracted with ethyl acetate (3 x 50 mL), washed with brine, concentrated to obtain the title compound methyl 2-cycloheptylacetate (5.18 g, 28.3 mmol, 92.9 % yield). LCMS m/z 171 .2 (M+H)+, 1 .82 min (Ret. time).
References:
WO2017/60854,2017,A1 Location in patent:Page/Page column 154
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