METHYL 2-(PYRIDIN-3-YL)OXAZOLE-4-CARBOXYLATE synthesis
- Product Name:METHYL 2-(PYRIDIN-3-YL)OXAZOLE-4-CARBOXYLATE
- CAS Number:1065102-69-3
- Molecular formula:C10H8N2O3
- Molecular Weight:204.18
500-22-1
478 suppliers
$6.00/5g
5680-80-8
449 suppliers
$10.00/5g
1065102-69-3
9 suppliers
$430.22/1g
Yield:1065102-69-3 71%
Reaction Conditions:
Stage #1: 3-pyridinecarboxaldehyde;methyl (2S)-2-amino-3-hydroxypropanoate hydrochloridewith magnesium sulfate;triethylamine in tetrahydrofuran at 20; for 12 h;
Stage #2: with Bromotrichloromethane;1,8-diazabicyclo[5.4.0]undec-7-ene in dichloromethane at 0 - 20; for 12 h;
References:
Graham, Thomas H. [Organic Letters,2010,vol. 12,# 16,p. 3614 - 3617] Location in patent:supporting information; experimental part
500-22-1
478 suppliers
$6.00/5g
5619-04-5
235 suppliers
$6.00/5g
1065102-69-3
9 suppliers
$430.22/1g