methyl (2E)-2-cyano-3-(4-nitrophenyl)prop-2-enoate synthesis

Yield:62985-31-3 92%

Reaction Conditions:

with C₄₄H₅₂CuN₈S₄⁽¹⁺⁾*BF₄^(1-) in methanol at 70; for 4 h;Schlenk technique;Inert atmosphere;Knoevenagel Condensation;

Steps:

4.2 General Procedure for KnoevenagelCondensation Reactions

General procedure: In a typical procedure, aldehyde (1 mmol), active methylenegroup compound (1.2 mmol), and catalyst (5 mol%) wereplaced in a Schlenk tube, and then methanol (2 mL) wasadded. The reaction mixture was stirred for 4 h under aerobicconditions. The reaction progress was monitored by TLC.After completion of the reaction, water was added to formthe precipitate. The precipitate was filtered and re-dissolvedin ethyl acetate, followed by flash column chromatographyto remove the catalyst.

References:

Mannarsamy, Maruthupandi;Prabusankar, Ganesan [Catalysis Letters,2022,vol. 152,# 8,p. 2327 - 2332]