Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate synthesis
- Product Name:Methyl 3-[(4-Hydroxyphenyl)aMino]propanoate
- CAS Number:70156-40-0
- Molecular formula:C10H13NO3
- Molecular Weight:195.22
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Yield:70156-40-0 75 %Chromat.
Reaction Conditions:
with nano copper(0) complex supported on pandanus nanocellulose in ethanol at 20; for 4 h;Michael Addition;
Steps:
2.8. General procedure of Aza-Michael addition reaction
General procedure: A mixture of Cu(0)NCPHA (5 mg), amine (1.0 mmol) and Michaelacceptor (1.5 mmol) in ethanol was stirred at room temperature and thereaction progress was monitored by TLC and GC analyses. After completeconsumption of amine, Cu(0)NC(at)PHA was separated by filtrationand the organic layer was concentrated under reduced pressure. Thecrude product was purified by silica gel column chromatography (ethylacetate/hexane) to give the corresponding n-aryl/alkylated product[15,26]. The chemical structures of all n-aryl/alkylated products weredetermined by using of GC-MS and NMR analysis (ESI, Fig. S3-S51).
References:
Jian Fui, Choong;Lutfor Rahman, Md;Musta, Baba;Sani Sarjadi, Mohd;Sarkar, Shaheen M.;Xin Ting, Tang [Polyhedron,2021,vol. 206]
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70156-42-2
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70156-40-0
25 suppliers
$130.00/500mg