METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE synthesis
- Product Name:METHYL 3,5-DIBROMO-2,4-DIHYDROXY-6-METHYLBENZOATE
- CAS Number:715-33-3
- Molecular formula:C9H8Br2O4
- Molecular Weight:339.97
39493-62-4
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715-33-3
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Yield:715-33-3 93%
Reaction Conditions:
with bromine;acetic acid in methanol at 20 - 45; for 19 h;
Steps:
1.2 (2) Synthesis of 2,4-dihydroxy-3,5-dibromo-6-methylbenzoic acid methyl ester (Compound 3)
After dissolving 15 g (0.081 mol) of compound 2 in 150 mL of glacial acetic acid, 50 mL of a solution of 39 g (0.243 mol) of bromine in glacial acetic acid was added dropwise at 45 ° C for 1 h and then transferred to room temperature for 18 h . The reaction solution was added to ice water, a large number of white solid was precipitated, filtered, the filter cake was collected, dried and the residue was purified by silica gel column chromatography (petroleum ether / acetone) to give a white solid 25g, the yield was 93%.
References:
CN104370738,2017,B Location in patent:Paragraph 0042; 0046; 0047
3187-58-4
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715-33-3
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39493-30-6
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715-33-3
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56157-27-8
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715-33-3
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