![](/CAS/GIF/4934-98-9.gif)
methyl 3-(benzyloxy)cyclobutanecarboxylate synthesis
- Product Name:methyl 3-(benzyloxy)cyclobutanecarboxylate
- CAS Number:4934-98-9
- Molecular formula:C13H16O3
- Molecular Weight:220.26
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
738 suppliers
$7.29/5ml-f
![3-benzyloxy-cyclobutanecarboxylic acid](/CAS/GIF/4958-02-5.gif)
4958-02-5
97 suppliers
$29.00/1g
![methyl 3-(benzyloxy)cyclobutanecarboxylate](/CAS/GIF/4934-98-9.gif)
4934-98-9
34 suppliers
$37.00/250mg
Yield: 94%
Reaction Conditions:
with thionyl chloride at 0 - 75; for 16 h;
Steps:
1 Step 1
To a solution of 3-benzyloxycyclobutanecarboxylic acid (10 g, 48.49 mmol, 1 eq) in methanol (100 mL) was added thionyl chloride (11.54 g, 96.98 mmol, 7.03 mL, 2 eq) dropwise at 0 °C, then heated to 75 °C and stirred for 16 h. The reaction mixture was concentrated to give a residue which was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 20/1 to 5/1). Methyl 3-benzyloxycyclobutanecarboxylate (10.13 g, 45.99 mmol, 94% yield) was obtained as a colorless oil.
References:
ARVINAS OPERATIONS, INC. WO2021/11913, 2021, A1 Location in patent:Paragraph 1341; 1342
![Cyclobutanecarboxylic acid, 3-hydroxy-, methyl ester](/CAS/GIF/4934-99-0.gif)
4934-99-0
86 suppliers
$21.00/1g
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
425 suppliers
$10.00/10 g
![methyl 3-(benzyloxy)cyclobutanecarboxylate](/CAS/GIF/4934-98-9.gif)
4934-98-9
34 suppliers
$37.00/250mg
![3-BENZYLOXYCYCLOBUTANE-1,1-DICARBOXYLIC ACID DIETHYL ESTER](/CAS/GIF/54166-15-3.gif)
54166-15-3
74 suppliers
$60.00/100mg
![methyl 3-(benzyloxy)cyclobutanecarboxylate](/CAS/GIF/4934-98-9.gif)
4934-98-9
34 suppliers
$37.00/250mg
![Benzene, [[2-broMo-1-(chloroMethyl)ethoxy]Methyl]-](/CAS/GIF/54307-67-4.gif)
54307-67-4
20 suppliers
$125.00/100mg
![methyl 3-(benzyloxy)cyclobutanecarboxylate](/CAS/GIF/4934-98-9.gif)
4934-98-9
34 suppliers
$37.00/250mg
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
425 suppliers
$10.00/10 g
![methyl 3-(benzyloxy)cyclobutanecarboxylate](/CAS/GIF/4934-98-9.gif)
4934-98-9
34 suppliers
$37.00/250mg