Methyl 3-broMo-5-Methylpyridine-2-carboxylate synthesis
- Product Name:Methyl 3-broMo-5-Methylpyridine-2-carboxylate
- CAS Number:1228880-68-9
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
67-56-1
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Yield:1228880-68-9 94 %
Reaction Conditions:
Stage #1: 3-bromo-5-methylpicolinonitrilewith sodium hydroxide in water;Inert atmosphere;Reflux;
Stage #2: methanolwith thionyl chloride at 50;Inert atmosphere;
References:
Sim, Kyu-Hyun;ul Ansari, Thameem;Park, Yong-Gyu;Jeong, Yeolib;Oh, Sang-Ha;Min, Hye-Won;Jeon, Da-Yoon;Kim, Hyunwoo;Cho, Cheon-Gyu [Angewandte Chemie - International Edition,2022,vol. 61,# 42,art. no. E202212016][Angew. Chem.,2022,vol. 134,# 42] Location in patent:supporting information