Methyl 3-chloro-4-forMylbenzoate synthesis
- Product Name:Methyl 3-chloro-4-forMylbenzoate
- CAS Number:74733-26-9
- Molecular formula:C9H7ClO3
- Molecular Weight:198.6
67-56-1
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Yield:74733-26-9 80%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;triethylamine at 60;
Steps:
161.1 Step 1: Preparation of methyl 3-chloro-4-formylbenzoate
A 500-mL round-bottom flask was charged with 4-bromo-2-chlorobenzaldehyde (20.0g, 91.1 mmol, 1.00 equiv), methanol (300 mL), [1,1'-bis(diphenylphosphino)ferrocene] dichloropalladium (6.68 g, 9.13 mmol, 0.10 equiv), triethylamine (27.7 g, 274 mmol, 3.00 equiv). CO was introduced in. The resulting solution was stirred overnight at 60 °C and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (15/85) to provide 14.5 g (80% yield) ofmethyl3-chloro-4-formylbenzoate as a white solid.
References:
WO2015/3002,2015,A1 Location in patent:Paragraph 00657; 00658
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56525-63-4
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74733-26-9
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