![](/CAS/GIF/57017-95-5.gif)
methyl 3-chloro-4-hydroxyphenylacetate synthesis
- Product Name:methyl 3-chloro-4-hydroxyphenylacetate
- CAS Number:57017-95-5
- Molecular formula:C9H9ClO3
- Molecular Weight:200.62
![3-CHLORO-4-HYDROXYPHENYLACETIC ACID](/CAS/GIF/33697-81-3.gif)
33697-81-3
160 suppliers
$19.07/5g
![methyl 3-chloro-4-hydroxyphenylacetate](/CAS/GIF/57017-95-5.gif)
57017-95-5
54 suppliers
$70.00/500mg
Yield:57017-95-5 100%
Reaction Conditions:
with sulfuric acid in methanol at 68; for 15 h;
Steps:
14.a a-[3-chloro-4-hydroxy-phenyl]-methyl acetate
1 ml of sulfuric acid is added to a solution of 10 g (53.6 mmol) of (3-chloro-4-hydroxy-phenyl)-acetic acid in 100 ml of methanol. The reaction mixture is stirred at 68° C. for 15 hours and then concentrated under vacuum. After adding 100 ml of water and 100 ml of ethyl acetate, the reaction mixture is extracted with ethyl acetate. The organic phases are combined, washed with saturated sodium chloride solution and then dried over magnesium sulfate, filtered, and evaporated. 11 g (100%) of (3-chloro-4-hydroxy-phenyl)-methyl acetate is obtained in the form of a light yellow oil.
References:
GALDERMA RESEARCH & DEVELOPMENT US2010/144884, 2010, A1 Location in patent:Page/Page column 17
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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$7.29/5ml-f
![3-CHLORO-4-HYDROXYPHENYLACETIC ACID](/CAS/GIF/33697-81-3.gif)
33697-81-3
160 suppliers
$19.07/5g
![methyl 3-chloro-4-hydroxyphenylacetate](/CAS/GIF/57017-95-5.gif)
57017-95-5
54 suppliers
$70.00/500mg
![3-CHLORO-4-HYDROXYPHENYLACETIC ACID](/CAS/GIF/33697-81-3.gif)
33697-81-3
160 suppliers
$19.07/5g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
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$33.00/5g
![methyl 3-chloro-4-hydroxyphenylacetate](/CAS/GIF/57017-95-5.gif)
57017-95-5
54 suppliers
$70.00/500mg
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766-51-8
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$20.00/25g
![methyl 3-chloro-4-hydroxyphenylacetate](/CAS/GIF/57017-95-5.gif)
57017-95-5
54 suppliers
$70.00/500mg
![3-CHLORO-4-METHOXYBENZYL CHLORIDE](/CAS/GIF/13719-57-8.gif)
13719-57-8
19 suppliers
inquiry
![methyl 3-chloro-4-hydroxyphenylacetate](/CAS/GIF/57017-95-5.gif)
57017-95-5
54 suppliers
$70.00/500mg