Methyl 3 - chloropropaniMidate hydrochloride synthesis
- Product Name:Methyl 3 - chloropropaniMidate hydrochloride
- CAS Number:77570-15-1
- Molecular formula:C5H11Cl2NO
- Molecular Weight:172.0529
67-56-1
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Yield:-
Reaction Conditions:
with hydrogenchloride in diethyl ether at -20 - 0; for 28 h;
Steps:
A solution of 3-chlorobutanenitrile (20 g, 193.1 mmol) in diethyl ether (100 mL) was treated with MeOH (7.41 g, 231 .7 mmol) and cooled to 0 °C. HCI gas was bubbled into the reaction mixture for 4 h at 0 °C. The reaction mixture was stirred at -20 °C for 24 h and reaction mixture was concentrated in vacuo. The solid residue obtained was washed with diethyl ether (3 x 100 mL), n-pentane (2 x 100 mL) and dried in vacuo at 45 °C to give methyl 4-chlorobutanimidate hydrochloride as a white solid.
References:
WO2016/131098,2016,A1 Location in patent:Page/Page column 126