METHYL 3'-CYANO[1,1'-BIPHENYL]-4-CARBOXYLATE synthesis

6synthesis methods

Product Name:METHYL 3'-CYANO[1,1'-BIPHENYL]-4-CARBOXYLATE
CAS Number:89900-92-5
Molecular formula:C15H11NO2
Molecular Weight:237.25

6952-59-6 Synthesis

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619-44-3
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METHYL 3'-CYANO[1,1'-BIPHENYL]-4-CARBOXYLATE

89900-92-5
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Yield:89900-92-5 87 %Chromat.

Reaction Conditions:

Stage #1: 3-cyanobromobenzenewith n-butyllithium in tetrahydrofuran;hexane at 0; for 1.63889E-05 h;Flow reactor;
Stage #2: with Trimethyl borate in tetrahydrofuran;hexane at 0; for 0.000555556 h;Flow reactor;
Stage #3: methyl 4-iodobenzoate in tetrahydrofuran;methanol;hexane at 120; for 0.156667 h;Flow reactor;Suzuki-Miyaura Coupling;Temperature;

References:

Nagaki;Hirose;Moriwaki;Mitamura;Matsukawa;Ishizuka;Yoshida [Catalysis science and technology,2016,vol. 6,# 13,p. 4690 - 4694]

619-42-1 Synthesis