![](/CAS/GIF/173290-17-0.gif)
Methyl 3-iodopyrazine-2-carboxylate synthesis
- Product Name:Methyl 3-iodopyrazine-2-carboxylate
- CAS Number:173290-17-0
- Molecular formula:C6H5IN2O2
- Molecular Weight:264.02
![Methyl 3-amino-2-pyrazinecarboxylate](/CAS/GIF/16298-03-6.gif)
16298-03-6
320 suppliers
$7.00/1g
![Methyl 3-iodopyrazine-2-carboxylate](/CAS/GIF/173290-17-0.gif)
173290-17-0
89 suppliers
$12.00/100mg
Yield: 44%
Reaction Conditions:
with diiodomethane;isopentyl nitrite in diiodomethane at 85 - 100; for 15 h;
Steps:
15 3-Iodopyrazine-2-carboxylic acid methyl ester (Reference compound No.15-1)
Reference Example 15 3-Iodopyrazine-2-carboxylic acid methyl ester (Reference compound No.15-1) Isoamyl nitrite (5.2 mL, 39 mmol) was added to a suspension of 3-aminopyrazine-2-carboxylic acid methyl ester (1.9 g, 12 mmol) in diiodomethane (20 mL) at 85°C, then the mixture was stirred at 100°C for 15 hours. The reaction mixture was allowed to stand and purified by silica gel column chromatography to give 1.4 g of the title reference compound as a pale yellow solid. (Yield 44%) 1H-NMR(500MHz,CDCl3) δ 4.04(s,3H),8.47(d,J = 2.1 Hz,1H),8.56(d,J = 2.1 Hz,1H)
References:
SANTEN PHARMACEUTICAL CO., LTD. EP1602647, 2005, A1 Location in patent:Page/Page column 58