ChemicalBook CAS DataBase List methyl 3-isocyanatopropanoate

methyl 3-isocyanatopropanoate synthesis

5synthesis methods

Product Name:methyl 3-isocyanatopropanoate
CAS Number:50835-77-3
Molecular formula:C5H7NO3
Molecular Weight:129.11

32315-10-9 Synthesis

32315-10-9
409 suppliers
$10.00/1g

3196-73-4 Synthesis

3196-73-4
325 suppliers
$6.00/5g

50835-77-3
31 suppliers
$89.00/1g

Yield:-

Reaction Conditions:

for 3 h;

Steps:

1 Synthesis of Compound B>
According to Scheme (Ill) shown above, methyl ester derivative, an intermediate of Compound B according to the invention was synthesized as follows. 985 mg (3.45 mmol) of leucomethylene blue synthesized above was placed in a 100 mL of round bottomed flask, 50 mL of DMF was added and stirred magnetically to dissolve. Isocyanato-β-alanine methyl ester prepared otherwise from 1.45 g (10.35 mmol) β-alanine methyl ester hydrochloric salt and 1.02 g (3.45 mmol) of triphosgene was added and the mixture was stirred for 3 hours. After the reaction, the reaction liquid was concentrated to dryness and purified with a column chromatography. Purification of the column chromatography afforded 1.317 g of deep blue powder.

References:

DOJINDO LABORATORIES;MURAI, Masaki;MATSUMOTO, Chiaki;SAKAMOTO, Ryo;OZEKI, Nobuyuki;ISHIYAMA, Munetaka US2019/270888, 2019, A1 Location in patent:Paragraph 0053; 0059