ChemicalBook CAS DataBase List methyl 3-oxododecanoate

methyl 3-oxododecanoate synthesis

13synthesis methods

Product Name:methyl 3-oxododecanoate
CAS Number:76835-64-8
Molecular formula:C13H24O3
Molecular Weight:228.33

67-56-1 Synthesis

67-56-1
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1,3-Dioxane-4,6-dione, 2,2-dimethyl-5-(1-oxodecyl)-

182359-65-5
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76835-64-8
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Yield:76835-64-8 96 %

Reaction Conditions:

Inert atmosphere;Reflux;

Steps:

General Procedure for the Methanolysis of the Meldrum 4a-b Acid Derivative (GP2)

General procedure: The meldrum 3a-c acid derivative (1.0 equiv.) was dissolved in excess methanol and the reaction flask was equipped with a reflux apparatus under an argon atmosphere. The reaction was heated at reflux for 2 hours, then the heating was stopped and the mixture allowed to cool spontaneously to room temperature and stirred overnight. The progress of the reaction was followed by TLC in an EtOAc/cyclohexane mixture at 1:1 and revealed in iodine. On completion, the solvent was removed under vacuum and the oily product was used raw in the following step.

References:

US2022/411397,2022,A1 Location in patent:Paragraph 0218-0220

38330-80-2 Synthesis