ChemicalBook CAS DataBase List methyl 4-(2-chloroacetyl)benzoate

methyl 4-(2-chloroacetyl)benzoate synthesis

5synthesis methods

Product Name:methyl 4-(2-chloroacetyl)benzoate
CAS Number:52540-22-4
Molecular formula:C10H9ClO3
Molecular Weight:212.63

1076-96-6 Synthesis

1076-96-6
124 suppliers
$31.00/250mg

52540-22-4
2 suppliers
inquiry

Yield:52540-22-4 73%

Reaction Conditions:

with tris(2,2'-bipyridyl)ruthenium dichloride;chloroform;[bis(acetoxy)iodo]benzene in chloroform at 20; for 12 h;Irradiation;

Steps:

2.3 Representative procedure for the synthesis of α-chloroketones

General procedure: A 5 mL oven-dried reaction vessel equipped with a magnetic stirrer bar was charged with styrene (1a, 20.8 mg,0.20 mmol), Ru(bpy)3Cl2 (1.92 mg, 0.003 mmol, 1.5 mol%), PhI(OAc)2 (64.4 mg, 0.20 mmol, 1.0 equiv.) and CHCl3(2c, 2.0 mL). The reaction vessel was exposed to blue LED (450-455 nm, 3 W) at room temperature in air withstirring for 12 h. After completion of the reaction, the mixture was concentrated to yield the crude product, which wasfurther purified by flash chromatography (silica gel, petroleum ether/ethyl acetate = 10:1 to 5:1) to give the desiredproduct 5a.

References:

Wang, Zhihui;Wang, Lei;Wang, Zhiming;Li, Pinhua;Zhang, Yicheng [Chinese Chemical Letters,2021,vol. 32,# 1,p. 429 - 432] Location in patent:supporting information

3609-53-8 Synthesis