ChemicalBook CAS DataBase List METHYL 4-AMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

METHYL 4-AMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE synthesis

4synthesis methods

Product Name:METHYL 4-AMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE
CAS Number:162085-97-4
Molecular formula:C6H9N3O2
Molecular Weight:155.15

METHYL 4-(TERT-BUTOXYCARBONYLAMINO)-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

500701-36-0
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METHYL 4-AMINO-1-METHYL-1H-IMIDAZOLE-2-CARBOXYLATE

162085-97-4
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Yield:162085-97-4 160 mg

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 0;Inert atmosphere;

Steps:

17 Preparation of Compound 49

Compound 48 (300 mg, 1.17 mmol) was dissolved in dichloromethane (1 mL), then trifluoroacetic acid (1 mL)was added at 0°C under a nitrogen atmosphere, and the mixture was stirred for 2 hours. The reaction mixture wasconcentrated under reduced pressure, then diluted with dichloromethane (30 mL), and washed with saturated aqueoussodium hydrogen carbonate solution (30 mL). The aqueous layer was extracted with dichloromethane (30 mL), and thecollected organic layers were dried over anhydrous sodium sulfate. Filtration and concentration were performed, therebyobtaining Compound 49 (160 mg). 1H-NMR (400 MHz, CDCl3) δ 6.37 (s, 1H), 3.92 (s, 3H). 3.90 (s, 3H), 3.56 (brs, 2H)EI-MS m/z : [M+H]+156.17.

References:

EP4086268,2022,A1 Location in patent:Paragraph 0195; 0199

METHYL 1-METHYL-4-NITRO-1H-IMIDAZOLE-2-CARBOXYLATE

169770-25-6
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162085-97-4
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References

120095-64-9 Synthesis

1-METHYL-4-NITRO-2-(TRICHLOROACETYL)-1H-IMIDAZOLE

120095-64-9
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$95.00/250mg

162085-97-4
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References

2,2,2-trichloro-1-(1-methyl-1H-imidazol-2-yl)ethan-1-one

30148-23-3
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162085-97-4
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References