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ChemicalBook CAS DataBase List Methyl 4-aMino-6-chloronicotinate
1256785-40-6

Methyl 4-aMino-6-chloronicotinate synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1.1: acetic anhydride; acetic acid / 1.5 h / 120 °C
1.2: 1 h / Cooling with ice
2.1: triethylamine; trichlorophosphate / 2 h / 0 - 120 °C
3.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 °C
4.1: sulfuric acid / 0.25 h / 0 °C
4.2: pH 4 - 10

References:

Luk, Kin-Chun US2012/184562, 2012, A1