Methyl 4-bromo-2-fluoro-5-methylbenzoate synthesis
- Product Name:Methyl 4-bromo-2-fluoro-5-methylbenzoate
- CAS Number:1253927-05-7
- Molecular formula:C9H8BrFO2
- Molecular Weight:247.06
67-56-1
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Yield:1253927-05-7 94%
Reaction Conditions:
with dichloro sulfoxide in methanol at 0 - 20; for 1.25 h;
Steps:
167.1 Step 1 :
To a mixture of 4-bromo-2-fluoro-5-methylbenzoic acid (1 g, 4.29 mmol) in MeOH (20 mL) at 0 °C was added thionyl chloride (3.13 mL, 42.9 mmol) dropwise over 15 minutes. The reaction mixture was slowly warmed to room temperature and stirred for 1 hour. The mixture was concentrated in vacuo to afford methyl 4-bromo-2-fluoro-5- methylbenzoate (1 g, 4.05 mmol, 94 % yield). MS (M+1) m/z: 247.0 (MH+). LC retention time 0.93 min [Al]
References:
WO2020/86503,2020,A1 Location in patent:Page/Page column 116-117