![](/CAS/GIF/117738-74-6.gif)
METHYL-4-BROMO-3-CHLOROBENZOATE synthesis
- Product Name:METHYL-4-BROMO-3-CHLOROBENZOATE
- CAS Number:117738-74-6
- Molecular formula:C8H6BrClO2
- Molecular Weight:249.49
![Chlorotrimethylsilane](/CAS/20180906/GIF/75-77-4.gif)
75-77-4
566 suppliers
$5.04/10
![4-BROMO-3-CHLOROBENZOIC ACID](/CAS/GIF/25118-59-6.gif)
25118-59-6
190 suppliers
$6.00/1g
![METHYL-4-BROMO-3-CHLOROBENZOATE](/CAS/GIF/117738-74-6.gif)
117738-74-6
75 suppliers
$43.00/250mg
Yield: 93%
Reaction Conditions:
in methanol at 20;
Steps:
56.A Step A: Methyl 4-bromo-3-chlorobenzoate:
To a suspension of 4-bromo-3- chlorobenzoic acid (1 .2 g; 5.18 mmol) in MeOH (HPLC grade; 10 ml) chlorotrimethylsilane (2 ml) was added and the resulting mixture was stirred over a weekend at room temperature. After evaporation of solvents under reduced pressure the residue was diluted to 60 ml with EtOAc, washed with 5% NaHC03 (2 x 10 ml), brine (20 ml), dried over anhydrous MgS04, filtered and filtrate evaporated to dryness to give a title compound (1 .2 g; 93%), as creamy solid. 1H-NMR (CDCI3) 8.09 (d, 1 H, J = 1 .4 Hz); 7.75 (dd, 1 H, J = 1 .4; 8.3 Hz); 6.68 (d, 1 H), J = 8.3 Hz); 3.91 (s, 3H).
References:
AKAAL PHARMA PTY LTD;GROBELNY, Damian W;GILL, Gurmit S WO2014/63199, 2014, A1 Location in patent:Page/Page column 87