ChemicalBook CAS DataBase List Methyl 4-(diMethylcarbaMoyl)benzoate

Methyl 4-(diMethylcarbaMoyl)benzoate synthesis

9synthesis methods

Product Name:Methyl 4-(diMethylcarbaMoyl)benzoate
CAS Number:21928-11-0
Molecular formula:C11H13NO3
Molecular Weight:207.23

7377-26-6 Synthesis

7377-26-6
205 suppliers
$7.00/5g

124-40-3
500 suppliers
$18.00/100ml

21928-11-0
15 suppliers
$157.00/1g

Yield:21928-11-0 91%

Reaction Conditions:

in tetrahydrofuran at 0 - 30;

Steps:

2

280 mL of 2.0 M dimethylamine tetrahydrofuran solution (2.0 eq) was added to a 1 L three-necked flask, and the solution was cooled to 0 to 10 °C. A solution of the above acid chloride in tetrahydrofuran was added dropwise to the cooled dimethylamine tetrahydrofuran solution. After the dropwise addition is completed, the reaction solution is heated to 20 to 30 ° C for 1 to 2 hours. After the reaction is completed, 20 mL of water is added and stirred for 10 minutes to quench the reaction. The mixture was allowed to stand, layered, and the aqueous phase was extracted with 300 mL of dichloromethane. The combined organic layers were concentrated to dryness to give 48.8 g, The yield was 91.0%.

References:

CN109942486,2019,A Location in patent:Paragraph 0061; 0062; 0064

1679-64-7 Synthesis