ChemicalBook CAS DataBase List methyl 4-ethynyl-2-hydroxybenzoate

methyl 4-ethynyl-2-hydroxybenzoate synthesis

5synthesis methods

Product Name:methyl 4-ethynyl-2-hydroxybenzoate
CAS Number:216443-97-9
Molecular formula:C10H8O3
Molecular Weight:176.17

Benzoic acid, 2-hydroxy-4-[2-(trimethylsilyl)ethynyl]-, methyl ester

170100-60-4
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216443-97-9
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Yield:216443-97-9 96%

Reaction Conditions:

with potassium carbonate in tetrahydrofuran;methanol at 20; for 3 h;

Steps:

9 Preparation of methyl 2-hydroxy-4-ethynylbenzoate (Compound 9B)

Compound 9A (0.79 g, 3.18 mmol)Dissolved in a mixed solution of 5 mL of methanol and tetrahydrofuran,Potassium carbonate (0.44 g, 3.18 mmol) was added, and the reaction was stirred at room temperature for 3 hours.After the reaction is completed, water is added, ethyl acetate is extracted, and dried.Purification of compound 9B by column chromatography with petroleum ether.Yellow solid (0.54 g, 96% yield).

References:

CN104045552,2019,B Location in patent:Paragraph 0158; 0159; 0162; 0163