![](/CAS/20150408/GIF/187222-18-0.gif)
Methyl 4-Methoxy-3,5-diMethylpicolinate synthesis
- Product Name:Methyl 4-Methoxy-3,5-diMethylpicolinate
- CAS Number:187222-18-0
- Molecular formula:C10H13NO3
- Molecular Weight:195.22
![2-Pyridinecarboxylicacid,4-hydroxy-3,5-dimethyl-(9CI)](/CAS/20180808/GIF/447461-21-4.gif)
447461-21-4
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![Methyl 4-Methoxy-3,5-diMethylpicolinate](/CAS/20150408/GIF/187222-18-0.gif)
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Yield:187222-18-0 65%
Reaction Conditions:
in N-methyl-acetamide;water;
Steps:
10 Synthesis of 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine from 2-carboxy-4-hydroxy-3,5-lutidine
EXAMPLE 10 Synthesis of 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine from 2-carboxy-4-hydroxy-3,5-lutidine Sodium hydride (60%, 2 eq.) was dissolved in dry dimethylformamide (5 volumes) and 2-carboxy-4-hydroxy-3,5-lutidine (1 eq.) was added. The mixture was stirred under a stream of nitrogen for 15 minutes and lodomethane (2.5 eq.) was added. The mixture was stirred at room temperature for 12 hours. Deionized water was added and the product was extracted three times with dichloromethane. The combined organic extracts were dried over sodium sulfate, filtered and the solvent was evaporated to give the 4-Methoxy-2-methoxycarbonyl-3,5-Lutidine product as a light brown oil in 65% yield.
References:
US6437139,2002,B1
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![Methyl 4-Methoxy-3,5-diMethylpicolinate](/CAS/20150408/GIF/187222-18-0.gif)
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![4H-Pyran-2-carboxylic acid, 3,5-dimethyl-4-oxo-](/CAS/20200611/GIF/187222-12-4.gif)
187222-12-4
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![Methyl 4-Methoxy-3,5-diMethylpicolinate](/CAS/20150408/GIF/187222-18-0.gif)
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![3,5-DiMethyl-2-(ethoxycarbonyl)-4-pyrone](/CAS/GIF/187222-13-5.gif)
187222-13-5
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$165.00/100mg
![Methyl 4-Methoxy-3,5-diMethylpicolinate](/CAS/20150408/GIF/187222-18-0.gif)
187222-18-0
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