Methyl 4-oxochromane-6-carboxylate synthesis
- Product Name:Methyl 4-oxochromane-6-carboxylate
- CAS Number:41118-19-8
- Molecular formula:C11H10O4
- Molecular Weight:206.19
67-56-1
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Yield:41118-19-8 86.2%
Reaction Conditions:
with thionyl chloride at 10 - 35;
Steps:
1.B B) methyl 4-oxochromane-6-carboxylate
To a solution of 4-oxochromane-6-carboxylic acid (400.0 mg, 2.60 mmol) in MeOH (-10 mL) was added S0C12 (569.7 mg, 4.80 mmol) dropwise. The mixture was stirred at room temperature overnight. Water was added, and the mixture was extracted with EtOAc. The organic layer was washed with brine, dried over Na2SO4, and concentrated in vacuo to give the title compound (370 mg, yield 86.2%) as white solids.
References:
WO2018/30550,2018,A1 Location in patent:Paragraph 0563
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49660-57-3
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201230-82-2
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41118-19-8
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41118-24-5
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41118-19-8
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6294-89-9
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41118-19-8
28 suppliers
$233.59/100mg
49660-57-3
216 suppliers
$7.00/250mg
41118-19-8
28 suppliers
$233.59/100mg