
methyl 4-sulphamoylbenzoate synthesis
- Product Name:methyl 4-sulphamoylbenzoate
- CAS Number:22808-73-7
- Molecular formula:C8H9NO4S
- Molecular Weight:215.23

67-56-1
762 suppliers
$9.00/25ml

138-41-0
315 suppliers
$11.00/25g

22808-73-7
42 suppliers
$96.00/100mg
Yield:22808-73-7 95%
Reaction Conditions:
with sulfuric acid for 8 h;Reflux;
Steps:
2 4.3.1 Synthetic procedure of methyl 4-sulfamoylbenzoate (6)
Commercially available, 73 4-sulfamoylbenzoic acid 5 (10mmol) was refluxed in dried 74 methanol with a catalytic amount of 75 conc. H2SO4 acid for 8h. After completion of the reaction, the mixture was poured into ice cold water and obtained precipitate was filtered and dried to give 11 methyl 4-sulfamoylbenzoate 6. 4.3.2 11 Methyl 4-sulfamoylbenzoate (6) (0035) White crystalline solid; yield 95%; mp: 148-150°C; 1H NMR (DMSO-d6,400MHz):δ 3.87 (s, 3H, OCH3), 7.55 (s, 2H, NH2), 7.94 (d, 2H, Ar, J=8.4Hz), 8.12 (d, 2H, Ar, J=8.4Hz); LC-MS: m/z; 216 (M+1).
References:
Mishra, Chandra Bhushan;Kumari, Shikha;Angeli, Andrea;Bua, Silvia;Buonanno, Martina;Monti, Simona Maria;Tiwari, Manisha;Supuran, Claudiu T. [European Journal of Medicinal Chemistry,2018,vol. 156,p. 430 - 443]

138-41-0
315 suppliers
$11.00/25g

18107-18-1
212 suppliers
$33.00/5g

22808-73-7
42 suppliers
$96.00/100mg

69812-51-7
115 suppliers
$39.00/1g

22808-73-7
42 suppliers
$96.00/100mg

138-41-0
315 suppliers
$11.00/25g

22808-73-7
42 suppliers
$96.00/100mg

70-55-3
578 suppliers
$6.00/100g

22808-73-7
42 suppliers
$96.00/100mg