METHYL 5'-AMINO-2,3'-BITHIOPHENE-4'-CARBOXYLATE synthesis

4synthesis methods

Product Name:METHYL 5'-AMINO-2,3'-BITHIOPHENE-4'-CARBOXYLATE
CAS Number:444907-56-6
Molecular formula:C10H9NO2S2
Molecular Weight:239.31

67-56-1 Synthesis

67-56-1
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2-amino-4-thiophen-2-yl-thiophene-3-carbonitrile

276670-60-1
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METHYL 5'-AMINO-2,3'-BITHIOPHENE-4'-CARBOXYLATE

444907-56-6
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Yield:444907-56-6 46%

Reaction Conditions:

sulfuric acidProduct distribution / selectivity;Heating / reflux;

Steps:

10.1

Intermediate (10) : Preparation of l-benzvM-chloro-S-thiophen-l-yl-thienori.S-dlpyrimidine; Step 1. Preparation of 5'-amino-[2.3'lbithiophenyl-4'-carboxylic acid methyl ester; The compound (lOOmg, 0.48mmol) prepared in the step 2 of example 8(method 2) was refluxed in catalyst amount of cone, sulfuric acid and methanol (5ml) to give21mg (yield: 46%, colorless solid) of the target compound. [520] ¹U NMR(400D, CDCI); δ 7.25(d, J=3.6Hz, IH), 7.01 (m, 2H), 6.22(s, IH), 6.1 l(s,2H), 3.67(s, 3H).

References:

WO2007/102679,2007,A1 Location in patent:Page/Page column 49-50

2-Butenoic acid, 2-cyano-3-(2-thienyl)-, methyl ester

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444907-56-6
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References

88-15-3
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444907-56-6
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References

2-[1-(2-THIENYL)ETHYLIDENE]MALONONITRILE

10432-44-7
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444907-56-6
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References