![](/CAS/GIF/192810-12-1.gif)
METHYL 5-BROMO-3-HYDROXYBENZOATE synthesis
- Product Name:METHYL 5-BROMO-3-HYDROXYBENZOATE
- CAS Number:192810-12-1
- Molecular formula:C8H7BrO3
- Molecular Weight:231.04
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
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$7.29/5ml-f
![3-BROMO-5-HYDROXYBENZOIC ACID](/CAS/GIF/140472-69-1.gif)
140472-69-1
174 suppliers
$19.00/250mg
![METHYL 5-BROMO-3-HYDROXYBENZOATE](/CAS/GIF/192810-12-1.gif)
192810-12-1
86 suppliers
$72.90/250mg
Yield:192810-12-1 97%
Reaction Conditions:
with acetyl chloride at 0 - 20;Inert atmosphere;
Steps:
Methyl 3-bromo-5-hydroxybenzoate
To a flask containing 3-bromo-5-hydroxybenzoic acid (2.0 g, 9.2 mmol) in anhydrous MeOH (10 mL) at 0°C under N2 was added AcCl (912 μ,, 12.9 mmol). The reaction mixture was allowed to warm to room temperature overnight. The mixture was diluted with EA and washed with NaHC03. The organic layers were dried and concentrated to provide 2.1g (97%) of methyl 3-bromo-5-hydroxybenzoate as a white solid. LCMS-ESI (m/z) calculated for C8H7Br03: 231.04; found 232.9 [M+H]+, tR = 3.06 min.
References:
RECEPTOS, INC.;MARTINBOROUGH, Esther;BOEHM, Marcus, F.;YEAGER, Adam, Richard;TAMIYA, Junko;HUANG, Liming;BRAHMACHARY, Enugurthi;MOORJANI, Manisha;TIMONY, Gregg, Alan;BROOKS, Jennifer, L.;PEACH, Robert;SCOTT, Fiona, Lorraine;HANSON, Michael, Allen WO2015/66515, 2015, A1 Location in patent:Page/Page column 105
![3-AMINO-5-BROMOBENZOATE](/CAS/GIF/706791-83-5.gif)
706791-83-5
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$8.00/250mg
![METHYL 5-BROMO-3-HYDROXYBENZOATE](/CAS/GIF/192810-12-1.gif)
192810-12-1
86 suppliers
$72.90/250mg
![METHYL 3,5-DIBROMOBENZOATE](/CAS/GIF/51329-15-8.gif)
51329-15-8
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$6.00/1g
![METHYL 5-BROMO-3-HYDROXYBENZOATE](/CAS/GIF/192810-12-1.gif)
192810-12-1
86 suppliers
$72.90/250mg
![3-Bromo-5-(methoxycarbonyl)benzeneboronic acid pinacol ester](/CAS/GIF/1025718-78-8.gif)
1025718-78-8
31 suppliers
$41.29/250mg
![METHYL 5-BROMO-3-HYDROXYBENZOATE](/CAS/GIF/192810-12-1.gif)
192810-12-1
86 suppliers
$72.90/250mg
![3-BROMO-5-HYDROXYBENZOIC ACID](/CAS/GIF/140472-69-1.gif)
140472-69-1
174 suppliers
$19.00/250mg
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
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![METHYL 5-BROMO-3-HYDROXYBENZOATE](/CAS/GIF/192810-12-1.gif)
192810-12-1
86 suppliers
$72.90/250mg