ChemicalBook CAS DataBase List Methyl 5-(bromomethyl)-2-thiophenecarboxylate

Methyl 5-(bromomethyl)-2-thiophenecarboxylate synthesis

6synthesis methods

Product Name:Methyl 5-(bromomethyl)-2-thiophenecarboxylate
CAS Number:108499-32-7
Molecular formula:C7H7BrO2S
Molecular Weight:235.1

19432-69-0
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$24.00/250mg

Methyl 5-(bromomethyl)-2-thiophenecarboxylate

108499-32-7
34 suppliers
$45.00/5mg

Yield: 100%

Reaction Conditions:

with N-Bromosuccinimide;dibenzoyl peroxide in chloroform for 7 h;Reflux;

Steps:

4 Preparation 4 Methyl 5-(bromomethyl)thiophene-2-carboxylate
Add freshly recrystallised NBS (323.8 g, 1.81 mol) to a solution of methyl-5- methylthiophene-2-carboxylate (258 g, 1.65 mol) in chloroform (2.6 L) at room temperature, and stir. Add benzoyl peroxide (3.99 g, 0.016 mol) and heat the reaction mixture to reflux for 7 hours. Cool the reaction mixture to ambient temperature and filter through diatomaceous earth. Wash the filter cake with chloroform (250 ml). Collect the organic layers and remove the solvent to give the title compound (388 g, 100%), which is used without further purification. ESI (m/z) 236(M+H).

References:

ELI LILLY AND COMPANY;HAMDOUCHI, Chafiq WO2013/25424, 2013, A1 Location in patent:Page/Page column 8

2-Thiophenecarboxylic acid, 5-(hydroxymethyl)-, methyl ester

530145-16-5
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108499-32-7
34 suppliers
$45.00/5mg

References

1918-79-2
238 suppliers
$8.00/5g

108499-32-7
34 suppliers
$45.00/5mg

References

19432-69-0
58 suppliers
$24.00/250mg

108499-32-7
34 suppliers
$45.00/5mg

methyl 5-(dibromomethyl)thiophene-2-carboxylate（WS204519）

1001200-44-7
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References

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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108499-32-7
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References