ChemicalBook CAS DataBase List Methyl 5-chloro-6-methylpyrazine-2-carboxylate

Methyl 5-chloro-6-methylpyrazine-2-carboxylate synthesis

5synthesis methods

Product Name:Methyl 5-chloro-6-methylpyrazine-2-carboxylate
CAS Number:77168-85-5
Molecular formula:C7H7ClN2O2
Molecular Weight:186.6

2-Pyrazinecarboxylic acid, 4,5-dihydro-6-Methyl-5-oxo-, Methyl ester

77168-84-4
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Methyl 5-chloro-6-methylpyrazine-2-carboxylate

77168-85-5
88 suppliers
$15.00/100mg

Yield:77168-85-5 52%

Reaction Conditions:

with trichlorophosphate in N,N-dimethyl-formamide;

Steps:

47 METHYL 5-CHLORO-6-METHYL-2-PYRAZINE CARBOXYLATE

Example 47 METHYL 5-CHLORO-6-METHYL-2-PYRAZINE CARBOXYLATE To a solution of methyl 4,5-dihydro-6-methyl-5-oxo-2-pyrazine carboxylate (M. Mano, T. Seo, K. Imai, Chem. Pharm. Bull 10:3057-3063, 1980) in DMF (20 mL) was added POCl₃ (20 mL). The reaction was refluxed for 0.5 h and then poured into ice. The aqueous layer was extracted with CHCl₃ dried (MgSO₄) and concentrated. The residue was chromatographed (SiO₂, CHCl₃) to provide the title compound (2.34 g, 52% yield); m.p. 49°-50° C.

References:

US5811428,1998,A

5-Methyl-6-oxo-1,6-dihydropyrazine-2,3-dicarbonitrile

57005-61-5
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77168-85-5
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References

5-hydroxy-6-methylpyrazine-2-carboxylic acid

77168-83-3
57 suppliers
$90.00/50mg

77168-85-5
88 suppliers
$15.00/100mg

References

2-Pyrazinecarboxylic acid, 3-(aminocarbonyl)-1,6-dihydro-5-methyl-6-oxo-

77168-81-1
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77168-85-5
88 suppliers
$15.00/100mg

References

6-methyl-5-oxo-4,5-dihydropyrazine-2-carboxamide

77168-82-2
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77168-85-5
88 suppliers
$15.00/100mg

References