ChemicalBook CAS DataBase List METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE

METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE synthesis

5synthesis methods

Product Name:METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE
CAS Number:78155-73-4
Molecular formula:C9H7FN2O2
Molecular Weight:194.16

67-56-1 Synthesis

67-56-1
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$9.00/25ml

1077-96-9 Synthesis

1077-96-9
132 suppliers
$52.00/250mg

METHYL 5-FLUORO-1H-INDAZOLE-3-CARBOXYLATE

78155-73-4
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$45.00/50mg

Yield:78155-73-4 57%

Reaction Conditions:

with sulfuric acid for 3 h;Reflux;

Steps:

B8.1

A solution of the above solid (1.62 g) in methanol (30 mL) was added with concentrated sulfuric acid (4 mL), and the mixture was refluxed for 3 hours by heating.
The reaction mixture was cooled to room temperature, and then poured into water (90 mL), and the precipitated solid was collected by filtration and washed with water to obtain methyl 5-fluoro-1H-indazole-3-carboxylate (1.35 g, 57%).
¹H NMR (300 MHz, DMSO-d₆) δ 3.92 (s, 3H), 7.37 (ddd, J = 2.2, 8.8, 9.5 Hz, 1H), 7.72 (d, J = 8.8 Hz, 1H), 7.73 (d, J = 9.5 Hz, 1H), 14.08 (br s, 1H).

References:

EP2565192,2013,A1 Location in patent:Paragraph 0350

67-56-1 Synthesis

67-56-1
746 suppliers
$9.00/25ml

201230-82-2 Synthesis