methyl 5-fluoro-2-(trifluoromethyl)benzoate synthesis
- Product Name:methyl 5-fluoro-2-(trifluoromethyl)benzoate
- CAS Number:773873-90-8
- Molecular formula:C9H6F4O2
- Molecular Weight:222.14
654-99-9
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773873-90-8
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Yield:-
Reaction Conditions:
in methanol;diethyl ether;chloroform; for 1 h;
Steps:
36
To a solution of 5-fluoro-2-(trifluoromethyl)benzoic acid (2.0 g, 9.62 mmol, Aldrich) in a mixture of chloroform and methanol (1 :1 , 40 ml) was added a 2 M solution of TMS- diazomethane in ether (approximately 8 ml) dropwise, in portions over about 1 h, allowing the solution to cool down between additions. The solution was evaporated in vacuo. To the residue was added chloroform (approximately 40 ml) and the solvent removed in vacuo to give methyl 5-fluoro-2-(trifluoromethyl)benzoate as a colourless slightly cloudy oil (2.09 g).
References:
WO2010/122089,2010,A1 Location in patent:Page/Page column 64-65