Methyl 5-(Methylsulfonyl)-2-nitrobenzoate synthesis

Yield:-

Reaction Conditions:

Stage #1: methyl 5-(methylthio)-2-nitrobenzoatewith potassium monopersulfate triple salt in methanol;water at 20; for 72 h;
Stage #2: methyl 5-fluoro-2-nitrobenzoate

Steps:

Compound 79C: methyl 5-(methylsulfonyl)-2-nitrobenzoate

Compound 79C: methyl 5-(methylsulfonyl)-2-nitrobenzoate To a solution of Oxone (2.03 g, 3.30 mmol) in H₂O (30 mL) was added a solution of 79B (500 mg, 2.20 mmol) in MeOH (10 mL). The mixture was stirred for 3 days. The solution was extracted with ethyl acetate, washed with water, dried over MgSO₄, concentrated under reduced pressure to compound 79C (510 mg). [M+H] calc'd for C₉H₉NO₆S, 260.0; found 260.0.

References:

US2007/213349,2007,A1 Location in patent:Page/Page column 73; 74