![](/CAS/20150408/GIF/851759-19-8.gif)
Methyl 6-chloro-2-Methylnicotinate synthesis
- Product Name:Methyl 6-chloro-2-Methylnicotinate
- CAS Number:851759-19-8
- Molecular formula:C8H8ClNO2
- Molecular Weight:185.61
![METHYL 6-HYDROXY-2-METHYLPYRIDINE-3-CARBOXYLATE](/CAS/GIF/223788-08-7.gif)
223788-08-7
39 suppliers
$140.00/250mg
![Methyl 6-chloro-2-Methylnicotinate](/CAS/20150408/GIF/851759-19-8.gif)
851759-19-8
46 suppliers
$145.00/250mg
Yield: 98.7%
Reaction Conditions:
with trichlorophosphate at 100; for 4 h;
Steps:
3 Step 3: Preparation of methyl 2-methyl-6-chloronicotinate
Add 500mL reaction flasks one by one6-hydroxy-2-methylnicotinic acid methyl ester (140g, 0.84mol),300 mL of phosphorus oxychloride,The reaction was heated to 100 ° C for 4 hours.Concentrated under reduced pressure,The residue was slowly poured into 1000 mL of ice water,A large amount of gray-black solid precipitated,Stir for 1 hour,Suction filtration,The cake was air-dried at room temperature.153 g of methyl 6-chloro-2-methylnicotinate was obtained, 98.7%.
References:
Shiyao Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.;Zhang Yan;Wei Miaomiao;Zhang Xuejiao;Mi Guorui;An Hui;Wei Bing;Guo Qian CN110878096, 2020, A Location in patent:Paragraph 0166; 0167; 0172; 0173
![3-Pyridinecarboxylic acid, 2-methyl-, methyl ester, 1-oxide](/CAS/20210305/GIF/1033809-42-5.gif)
1033809-42-5
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inquiry
![Methyl 6-chloro-2-Methylnicotinate](/CAS/20150408/GIF/851759-19-8.gif)
851759-19-8
46 suppliers
$145.00/250mg
![METHYL 2-(CHLOROMETHYL)NICOTINATE](/CAS/GIF/177785-14-7.gif)
177785-14-7
46 suppliers
$185.00/100mg
![Methanol](/CAS/GIF/67-56-1.gif)
67-56-1
737 suppliers
$7.29/5ml-f
![3-PYRIDINECARBOXYLIC ACID, 6-CHLORO-2-METHYL-](/CAS/GIF/137129-98-7.gif)
137129-98-7
120 suppliers
$14.00/100mg
![Methyl 6-chloro-2-Methylnicotinate](/CAS/20150408/GIF/851759-19-8.gif)
851759-19-8
46 suppliers
$145.00/250mg
![3-Pyridinecarboxylic acid, 2-methyl-, methyl ester, 1-oxide](/CAS/20210305/GIF/1033809-42-5.gif)
1033809-42-5
1 suppliers
inquiry
![Methyl 6-chloro-2-Methylnicotinate](/CAS/20150408/GIF/851759-19-8.gif)
851759-19-8
46 suppliers
$145.00/250mg
![Methyl 2-methylnicotinate](/CAS/GIF/65719-09-7.gif)
65719-09-7
188 suppliers
$21.00/1g
![Methyl 6-chloro-2-Methylnicotinate](/CAS/20150408/GIF/851759-19-8.gif)
851759-19-8
46 suppliers
$145.00/250mg