ChemicalBook CAS DataBase List Methyl 6-chloro-2-Methylnicotinate

Methyl 6-chloro-2-Methylnicotinate synthesis

6synthesis methods

Product Name:Methyl 6-chloro-2-Methylnicotinate
CAS Number:851759-19-8
Molecular formula:C8H8ClNO2
Molecular Weight:185.61

223788-08-7 Synthesis

METHYL 6-HYDROXY-2-METHYLPYRIDINE-3-CARBOXYLATE

223788-08-7
39 suppliers
$140.00/250mg

851759-19-8
46 suppliers
$145.00/250mg

Yield: 98.7%

Reaction Conditions:

with trichlorophosphate at 100; for 4 h;

Steps:

3 Step 3: Preparation of methyl 2-methyl-6-chloronicotinate
Add 500mL reaction flasks one by one6-hydroxy-2-methylnicotinic acid methyl ester (140g, 0.84mol),300 mL of phosphorus oxychloride,The reaction was heated to 100 ° C for 4 hours.Concentrated under reduced pressure,The residue was slowly poured into 1000 mL of ice water,A large amount of gray-black solid precipitated,Stir for 1 hour,Suction filtration,The cake was air-dried at room temperature.153 g of methyl 6-chloro-2-methylnicotinate was obtained, 98.7%.

References:

Shiyao Group Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd.;Zhang Yan;Wei Miaomiao;Zhang Xuejiao;Mi Guorui;An Hui;Wei Bing;Guo Qian CN110878096, 2020, A Location in patent:Paragraph 0166; 0167; 0172; 0173