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methyl 6-ethynylnicotinate synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: caesium carbonate / acetonitrile
2: N-ethyl-N,N-diisopropylamine; PdCl2(Ph3)2; copper(l) iodide; triphenylphosphine / 110 °C
3: potassium carbonate

References:

Li, Guo;Low, Philip S. [Bioorganic and Medicinal Chemistry Letters,2017,vol. 27,# 9,p. 2074 - 2078]

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