Methyl b-amino-3-chloro-benzenepropanoate HCl synthesis
1synthesis methods
- Product Name:Methyl b-amino-3-chloro-benzenepropanoate HCl
- CAS Number:277745-44-5
- Molecular formula:C10H12ClNO2
- Molecular Weight:213.66
Yield:277745-44-5 87%
Reaction Conditions:
Stage #1: methanol;3-amino-3-(3-chloro-phenyl)-propionic acidwith thionyl chloride at -10 - 20;
Stage #2: with sodium hydrogencarbonate in water;ethyl acetate; pH=7;
References:
WO2004/20432,2004,A1 Location in patent:Page/Page column 48