methyl2-bromo-4-chloro-5-methoxybenzoate synthesis
- Product Name:methyl2-bromo-4-chloro-5-methoxybenzoate
- CAS Number:1138220-77-5
- Molecular formula:C9H8BrClO3
- Molecular Weight:279.52
116022-18-5
68 suppliers
$50.00/25g
1138220-77-5
6 suppliers
inquiry
Yield:1138220-77-5 99%
Reaction Conditions:
with bromine;acetic acid in water at 60; for 1 h;
Steps:
27 Preparation 27 Methyl 2-bromo-4-chloro-5-methoxybenzoate
Preparation 27 Methyl 2-bromo-4-chloro-5-methoxybenzoate To a suspension of methyl 4-chloro-3-methoxybenzoate (Preparation 41 , 2.61 g, 13.0 mmol) in AcOH (10 mL) and water (10 mL) was added bromine (1 mL, 20 mmol) dropwise over 10 minutes. The reaction was heated to 60°C for 1 hour. The reaction was cooled to room temperature, and the resulting precipitate filtered, washed with water (2 x 20 mL) and dried to afford the title compound as a yellow solid (3.60 g, 99%). 1 H NMR (400 MHz, CDCI3): δ ppm 3.93 (s, 3H), 3.94 (s, 3H), 7.38 (s, 1 H), 7.66 (s, 1 H).
References:
WO2015/189744,2015,A1 Location in patent:Page/Page column 68-69
85740-98-3
155 suppliers
$9.00/250mg
1138220-77-5
6 suppliers
inquiry