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ChemicalBook CAS DataBase List Metizolam
40054-68-0

Metizolam synthesis

3synthesis methods
40054-40-8 Synthesis
5-(O-CHLOROPHENYL)-7-ETHYL-1,2-DIHYDRO-3H-THIENO[2,3-E][1,4]DIAZEPINE-2-THIONE

40054-40-8
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Metizolam

40054-68-0
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Yield:-

Steps:

Multi-step reaction with 2 steps
1: N2H4*H2O / methanol / Ambient temperature
2: H2SO4 / ethanol / 5 h / Heating

References:

Tahara;Araki;Shiroki;Matsuo;Munakata [Arzneimittel-Forschung/Drug Research,1978,vol. 28,# 7,p. 1153 - 1158]