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MFCD00545224 synthesis

11synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 1.) n-butyl-lithium / 1.) hexane, THF, -110 deg C, 3 h; 2.) THF, hexane, -105 deg C, 1 h; -78 deg C, 3 h
2: 53 percent / 1.2M aq. potassium hydroxide / methanol / 1.5 h / Heating

References:

Fleming, Ian;Loreto, Maria Antonietta;Wallace, Ian H.M.;Michael, Joseph P. [Journal of the Chemical Society. Perkin transactions I,1986,p. 349 - 360]