Mirtazapine synthesis
- Product Name:Mirtazapine
- CAS Number:85650-52-8
- Molecular formula:C17H19N3
- Molecular Weight:265.35
61337-89-1
166 suppliers
$51.00/1g
85650-52-8
288 suppliers
$5.00/10mg
Yield:85650-52-8 99.8%
Reaction Conditions:
with sulfuric acid in 1,2-dichloro-benzene at 50; for 15 h;Solvent;Temperature;
Steps:
1-7 Example 2
1-(3-hydroxymethylpyridine)-2-phenyl-4-methyl-piperazine 10g (1 equivalent) was placed in 30ml of 1,2-dichlorobenzene (39g, weight ratio 1:3.9) and dissolved at 55 for 60 minutes made it27.7 g (8 equivalents) of sulfuric acid was added to the reaction solution and stirred for 15 hours until the reaction was completed at 50°C.After completion of the reaction, after cooling to room temperature, 100 ml of water was added to the reaction solution, and extraction was performed to remove 1,2-dichlorobenzene.In the same manner as in the work-up procedure of Example 1, mirtazapine 9.35 g (HPLC: 99.2%) yield: 99.8% was obtained as a slightly dark white solid.
References:
KR2022/77981,2022,A Location in patent:Paragraph 0026; 0044-0097
61338-13-4
139 suppliers
$41.00/100mg
85650-52-8
288 suppliers
$5.00/10mg
75-75-2
644 suppliers
$10.00/5g
61337-89-1
166 suppliers
$51.00/1g
85650-52-8
288 suppliers
$5.00/10mg
![Pyrazino[2,1-a]pyrido[2,3-c][2]benzazepin-10-ol, 1,2,3,4,10,14b-hexahydro-2-methyl-](/CAS/20210305/GIF/1071838-96-4.gif)
1071838-96-4
0 suppliers
inquiry
85650-52-8
288 suppliers
$5.00/10mg
191546-96-0
51 suppliers
$160.00/1mg
85650-52-8
288 suppliers
$5.00/10mg