ChemicalBook CAS DataBase List Mono-tert-butyl succinate

Mono-tert-butyl succinate synthesis

9synthesis methods

Product Name:Mono-tert-butyl succinate
CAS Number:15026-17-2
Molecular formula:C8H14O4
Molecular Weight:174.19

108-30-5 Synthesis

108-30-5
618 suppliers
$5.00/25g

75-65-0 Synthesis

75-65-0
742 suppliers
$10.00/10ml

15026-17-2
149 suppliers
$6.00/1g

Yield:15026-17-2 100%

Reaction Conditions:

with dmap;1-hydroxy-pyrrolidine-2,5-dione in toluene for 48 h;Reflux;

Steps:

4-(tert-Butoxy)-4-oxobutanoic Acid
The monoester of succinate was prepared as described by Srinivasan,Uttamchandani and Yao [42]: Tert-butanol (10 mL) was added to asolution of succinic anhydrate (6.04 g, 60.40 mmol), Nhydroxysuccinimid (2.53g, 22.01 mmol) and DMAP (0.88 g, 7.23 mmol) in toluene (100 mL)and the solution was heated for 48 h under reflux conditions. After cooling down to rt, twolayers formed in the reaction vessel (brown oil and clear, colourless solution). The crudesolution was diluted with EtOAc (50 mL) and washed with citric acid (10 %, 2 × 50 mL) andbrine. The organic layer was dried over Na2SO4, the solvent evaporated and the crude productwas recrystallized from Et2O/PE (1:3, 25 mL) to yield the title compound in quantitativeyield.

References:

Wünsch, Matthias;Schröder, David;Fröhr, Tanja;Teichmann, Lisa;Hedwig, Sebastian;Janson, Nils;Belu, Clara;Simon, Jasmin;Heidemeyer, Shari;Holtkamp, Philipp;Rudlof, Jens;Klemme, Lennard;Hinzmann, Alessa;Neumann, Beate;Stammler, Hans-Georg;Sewald, Norbert [Beilstein Journal of Organic Chemistry,2017,vol. 13,p. 2428 - 2441] Location in patent:supporting information

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