ChemicalBook CAS DataBase List MORPHOLINE-4-SULFONYL CHLORIDE

MORPHOLINE-4-SULFONYL CHLORIDE synthesis

5synthesis methods

Product Name:MORPHOLINE-4-SULFONYL CHLORIDE
CAS Number:1828-66-6
Molecular formula:C4H8ClNO3S
Molecular Weight:185.63

110-91-8 Synthesis

110-91-8
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1828-66-6
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$8.00/1g

Yield:1828-66-6 100%

Reaction Conditions:

with sulfuryl dichloride in acetonitrile for 24 h;Heating / reflux;

Steps:

126
Morpholine (0.436 mL, 5 mmol) was added slowly and with caution to a mixture of sulfuryl chloride (1.205 mL, 15 mmol) in 5 mL acetonitrile. Heated to reflux and stirred for 24 hours. After starting material consumed, solution concentrated to oil, azeotroped with toluene (2x), concentrated to give crude product 126 stored as a 2M solution in dichloromethane (0.999 g, 5 mmol, 100%. ) ¹H NMR (CD3SOCD3) No. 3.80 (br s, 4H), 3.28 (br s, 4H.) MS: 186 (M+1)

References:

GILEAD SCIENCES, INC.;CAI, Zhenhong, R.;CHEN, Xiaowu;FARDIS, Maria;JABRI, Salman, Y.;JIN, Haolun;KIM, Choung, U.;METOBO, Sanuel, E.;MISH, Michael, R.;PASTOR, Richard, M. WO2005/117904, 2005, A2 Location in patent:Page/Page column 463-464

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110-91-8 Synthesis

110-91-8
693 suppliers
$9.00/1g