MPEG16-NH2 synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: triethylamine; methanesulfonyl chloride / dichloromethane / 6 h / 0 - 20 °C / Inert atmosphere
1.2: 144 h / 20 °C / Inert atmosphere
2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

References:

Wang, Xiang;Gan, Quan;Wicher, Barbara;Ferrand, Yann;Huc, Ivan [Angewandte Chemie - International Edition,2019,vol. 58,# 13,p. 4205 - 4209][Angew. Chem.,2019,vol. 131,# 13,p. 4249 - 4253,5]