N - (1 - (4' - broMophenyl)vinyl)acetaMide synthesis

5synthesis methods

Product Name:N - (1 - (4' - broMophenyl)vinyl)acetaMide
CAS Number:177750-12-8
Molecular formula:C10H10BrNO
Molecular Weight:240.1

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N - (1 - (4' - broMophenyl)vinyl)acetaMide

177750-12-8
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Yield:177750-12-8 72%

Reaction Conditions:

Stage #1: para-bromoacetophenonewith titanium(IV) isopropylate;ammonia in methanol;toluene; for 0.166667 h;Inert atmosphere;Cooling with ice;
Stage #2: acetic anhydridewith triethylamine at 5 - 20;

References:

Reeves, Jonathan T.;Tan, Zhulin;Han, Zhengxu S.;Li, Guisheng;Zhang, Yongda;Xu, Yibo;Reeves, Diana C.;Gonnella, Nina C.;Ma, Shengli;Lee, Heewon;Lu, Bruce Z.;Senanayake, Chris H. [Angewandte Chemie - International Edition,2012,vol. 51,# 6,p. 1400 - 1404] Location in patent:supporting information; experimental part