N-(1-CYANOCYCLOHEXYL)ACETAMIDE synthesis
- Product Name:N-(1-CYANOCYCLOHEXYL)ACETAMIDE
- CAS Number:4550-68-9
- Molecular formula:C9H14N2O
- Molecular Weight:166.22
Yield:4550-68-9 52%
Reaction Conditions:
with trimethylamine in diethyl ether at 20;Cooling with ice;
Steps:
1.2 1.2 Synthesis of N-(1 -cyanocyclohexyl)-acetamide
To a stirred solution of aminonitrile (474 mg, 3.62 mmol) and trimethylamine (0.6 mL, 4.28 mmol) in anhydrous Et20 (6 mL) cooled in an ice bath was added dropwise acetyl chloride (0.3 mL, 4.28 mmol) by syringe. The bath was removed and the reaction was stirred at rt for 3.5 hours. Then, the mixture was filtered through a fritted-glass funnel (medium porosity), and the Et20 was discarded. Using a second filter flask, the filter cake was washed 4 times with EtOAc. The EtOAc extracts were collected and evaporated to yield 311.7 mg (52% yield) of target compound as a white solid that did not require purification for subsequent reactions.1H NMR (200 MHz, CDCI3) d 7.08 (s, 1 H), 2.40-2.19 (m, 2H), 1.96 (s, 3H), 1.80-1.40 (m, 8H).
References:
WO2020/94454,2020,A1 Location in patent:Page/Page column 27
151-50-8
4 suppliers
$43.36/100g
108-94-1
528 suppliers
$12.00/50g
108-24-7
5 suppliers
$14.00/250ML
4550-68-9
8 suppliers
inquiry