ChemicalBook CAS DataBase List 2-Hexanamidoacetic acid

2-Hexanamidoacetic acid synthesis

6synthesis methods

Product Name:2-Hexanamidoacetic acid
CAS Number:24003-67-6
Molecular formula:C8H15NO3
Molecular Weight:173.21

56-40-6 Synthesis

56-40-6
1215 suppliers
$5.00/25g

142-62-1 Synthesis

142-62-1
445 suppliers
$13.80/2.5g

24003-67-6
50 suppliers
$35.00/10mg

Yield: 96%

Reaction Conditions:

Stage #1:hexanoic acid with 1,1'-carbonyldiimidazole in dichloromethane at 20; for 0.5 h;
Stage #2:glycine in dichloromethane for 12 h;

Steps:

(21) General Procedure for Amide Coupling
General procedure: To a stirred solution of the fatty acid (1.0 mmol, 1.0 equiv.) inCH2Cl2 (5 mL) was added CDI (0.178 g, 1.1 mmol, 1.1 equiv.).After 30 min at room temperature, the amine (1.1 mmol, 1.1equiv.) was added. After 12 h, CH2Cl2 (25 mL) was added, followedby saturated aqueous NH4Cl. The mixture was acidified topH 2 by addition of HCl, the organic phase was separated, andthe aqueous layer was further extracted with CH2Cl2 (3 × 10mL). The organic phases were combined, dried over Na2SO4, filtered,and concentrated in vacuo, to give the amide.

References:

Johansson, Silje J. R.;Johannessen, Tonje;Ellefsen, Christiane F.;Ristun, Mali S.;Antonsen, Simen;Hansen, Trond V.;Stenstrom, Yngve;Nolsoe, Jens M. J. [Synlett,2019,vol. 30,# 2,art. no. ST-2018-D0672-L,p. 213 - 217] Location in patent:supporting information

50-00-0 Synthesis