N-[2-(1H-BENZOIMIDAZOL-2-YL)-ETHYL]-BENZAMIDE synthesis

4synthesis methods

Product Name:N-[2-(1H-BENZOIMIDAZOL-2-YL)-ETHYL]-BENZAMIDE
CAS Number:107313-47-3
Molecular formula:C16H15N3O
Molecular Weight:0

29518-68-1 Synthesis

29518-68-1
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98-88-4 Synthesis

98-88-4
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N-[2-(1H-BENZOIMIDAZOL-2-YL)-ETHYL]-BENZAMIDE

107313-47-3
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Yield:107313-47-3 76%

Reaction Conditions:

with triethylamine in tetrahydrofuran; for 3 h;Reflux;

Steps:

4.1.6. General procedures for the acylation of (1H-benzimidazole-2-yl)alkylamines

General procedure: Starting amino compound (0.238 mmol) was dissolved in THF (25 mL) and triethylamine (10 drops) was added to the stirred solution. Acyl halide (0.149 mmol) was added dropwise to the stirred solution, which was then heated under reflux for 3h. The reaction mixture was concentrated under reduced pressure. The residue was dissolved in EtOAc and washed with aq. K₂CO₃ solution followed by brine. The organic layer was then dried over Na₂SO₄, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography eluting with 1-5 methanol/DCM v/v.

References:

Elshihawy, Hosam;Helal, Mohamed A.;Said, Mohamed;Hammad, Mohamed A. [Bioorganic and Medicinal Chemistry,2014,vol. 22,# 1,p. 550 - 558]

98-88-4 Synthesis

98-88-4
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$10.00/5g

95-54-5 Synthesis