N-(2,2-DIETHOXY-ETHYL)-2-PROPANAMINE synthesis
- Product Name:N-(2,2-DIETHOXY-ETHYL)-2-PROPANAMINE
- CAS Number:69128-20-7
- Molecular formula:C9H21NO2
- Molecular Weight:175.27
645-36-3
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75-26-3
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69128-20-7
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$57.50/250mg
Yield:69128-20-7 70%
Reaction Conditions:
with potassium carbonate in acetonitrile at 80; for 16 h;
Steps:
4 Production Example 4: Synthesis of Intermediate D-12
A solution of 2 -bromopropane (300 g, 2.44 mol) , 2,2- diethoxyethanamine (341 g, 2.56 mol) and potassium carbonate (674 g, 4.88 mol) in MeCN (3.0 L) was stirred at 80°C for 16 hrs. The solution was filtered and the filtrate was concentrated. The crude product was dissolved in ethyl acetate (2.0 L) , washed with water (1.0 L) and brine (1.0 L) ; dried over anhydrous sodium sulfate, and then filtered and evaporated to give the desired product of D-12 (300 g, 1.71 mol, 70% yield) as yellow oil, which was used for next step without purification.XH NMR (400 MHz, CDCI3) data of D-12 is shown in Fig. 5.
References:
WO2022/75486,2022,A1 Location in patent:Page/Page column 61
75-31-0
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2032-35-1
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69128-20-7
15 suppliers
$57.50/250mg