N-(2,6-dimethylphenyl)-glycine, ethyl ester synthesis

4synthesis methods

Product Name:N-(2,6-dimethylphenyl)-glycine, ethyl ester
CAS Number:2371-25-7
Molecular formula:C12H17NO2
Molecular Weight:207.27

105-36-2 Synthesis

105-36-2
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87-62-7
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N-(2,6-dimethylphenyl)-glycine, ethyl ester

2371-25-7
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Yield:2371-25-7 72%

Reaction Conditions:

with sodium acetate in ethanol at 80; for 6 h;

Steps:

Method for the synthesis of ethyl [(2,6-dimethylphenyl)amino]acetate (2b)

Ethyl[(2,6-dimethylphenyl)amino]acetate (2b) was obtained by stirring a mixture of 2,6-dimethylaniline (1) (0.1 mol; 12.2 g ~ 12.5 ml) and ethylbromoacetate (0.2 mol; ~33.0 ml) and anhydrous sodium acetatetrihydrate in ethanol for 6 h, as a creamy solid. This method of synthesis is somewhat faster than the reportedmethod mentioned earlier in which ethylchloroacetate was taken [3]. Yield 72%; M.p. 142-144 °C (found) and140 °C (reported) [3].

References:

Ahsan, Mohamed Jawed;Yadav, Raghunath Prasad;Saini, Saroj;Hassan, Mohd. Zaheen;Bakht, Mohammed Afroz;Jadav, Surender Singh;Al-Tamimi, Abdulmalik Bin Saleh;Geesi, Mohammed H.;Ansari, Md Yousuf;Khalilullah, Habibullah;Riadi, Yassine [Letters in Organic Chemistry,2018,vol. 15,# 1,p. 49 - 56] Location in patent:supporting information

105-39-5 Synthesis