N-(2-Chlorophenyl)-1H-pyrazole-3-carboxamide synthesis

Yield:305346-16-1 55%

Reaction Conditions:

with dmap at 120; for 0.5 h;

Steps:

30a Example 30; 1-Oleoyl-1H-pyrazole-3-carboxylic acid (2-chlorophenyl) amide; (a) 1H-Pyrazole-3-carboxylic acid (2-chlorophenyl)amide

A mixture of dipyrazolo[1,5-a ; 1',5'-d]pyrazine-4,9-dione (1.88 g, 10 mmol ; see Example 6 (A)), 2-CHLOROANILINE (6.38 g, 50 mmol) and 4-(N, N- dimethylamino) pyridine (1.22 g, 10 mmol) was stirred at 120°C for 30 min. After cooling to room temperature, ETOH (20 mL), followed by water (100 mL) and isohexane (100 mL) was added. The mixture was shaken for 10 min. The solid was filtered off, washed with 50% aqueous ETOH (20 mL), water (50 mL) and isohexane (50 mL), and dried in vacuum, to give the sub-title compound (yield: 2.45 g, 55%).

References:

WO2004/80999,2004,A1 Location in patent:Page 56