N-(2-FLUOROPHENYL)-3-AMINOPROPIONIC ACID synthesis
- Product Name:N-(2-FLUOROPHENYL)-3-AMINOPROPIONIC ACID
- CAS Number:38470-19-8
- Molecular formula:C9H10FNO2
- Molecular Weight:183.18
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38470-19-8
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Yield:38470-19-8 64%
Reaction Conditions:
Stage #1: 2-Fluoroaniline;acrylic acid methyl esterwith acetic acid at 80; for 8 h;
Stage #2: with water;sodium hydroxide in methanol at 94; for 20 h;
Steps:
1.1 (1) Synthesis of 3-(o-fluorophenylamino)propionic acid
To a 250 mL round bottom flask was added 13.74 mmol of 2-fluoroaniline,16.48 mmol of methyl acrylate,3.435 mmol of glacial acetic acid,Heating at 80 ° C for 8 h;Then add 58 mmol of sodium hydroxide,25mL water,25mL of methanol,At 94 ° C,Hydrolysis reaction occurred in a round bottom flask for 20 h;Tracking the response with TLC,After the reaction is completed,Cool to room temperature (20 ~ 25 ° C),Adjust the pH to 4-5 with concentrated hydrochloric acid.Extracted with 25 mL of ethyl acetate until the organic layer was colorless;then,The solvent is removed by a rotary evaporator.Obtaining a white solid product,That is 3-(o-fluorophenylamino)propionic acid,The yield is 64%.
References:
CN109503478,2019,A Location in patent:Paragraph 0076-0079
348-54-9
412 suppliers
$10.00/1g
79-10-7
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$20.50/500ml
38470-19-8
19 suppliers
$35.00/250mg